It is widely accepted that cancer cells have a significantly altered genomic and metabolic makeup relative to normal cells, but how can we best target these differences?  By combining our expertise in metabolism and therapeutic protein engineering, are working to engineer proteins to directly target and fight cancer.  For instance, certain enzymes can control the metabolic environment around tumors to inhibit their growth or to stimulate a native anti-cancer immune response.  We utilize directed evolution approaches to optimize protein function and efficacy.